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Confocal Microscopy Methods and Protocols Stephen W. Confocal Laser Scanning Microscopy In recent years, the confocal Laser Scanning Micro-scope (LSM) has become widely established as a research instrument. The present brochure aims at giving a scientifically sound survey of the special nature of image forma-tion in a confocal LSM. LSM applications in biology and medicine predomi- Confocal microscopy is a technique in optical imaging that uses point illumination via a spatial pinhole to eliminate outof-focus signals. The excitation light in confocal microscopy is usually provided by a laser to generate high intensities of fluorescence or reflectance from the focal spot..
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